01 - Combine mayonnaise, Dijon mustard, relish, hot sauce, lemon juice, minced garlic, smoked paprika, salt, and pepper in a small bowl. Mix thoroughly and refrigerate until ready to serve.
02 - In a shallow bowl, whisk together flour, cornmeal, Cajun seasoning, garlic powder, paprika, salt, and black pepper until well combined.
03 - In a separate bowl, whisk eggs and milk together until fully blended.
04 - Dip each shrimp into the egg mixture, allowing excess to drip off, then press firmly into the flour-cornmeal mixture to coat evenly on all sides.
05 - Pour approximately 2 inches of vegetable oil into a large skillet or Dutch oven. Heat to 350°F.
06 - Cook shrimp in batches for 2 to 3 minutes per side until golden brown and crispy. Transfer to paper towels to drain excess oil.
07 - Lightly toast the rolls if desired. Spread a generous layer of remoulade sauce on both halves of each roll.
08 - Layer shredded lettuce, tomato slices, pickles, and fried shrimp onto the bottom half of each roll. Add additional remoulade sauce if preferred, then top with the remaining bread half.
09 - Serve the po boy sandwiches while the shrimp remains hot and crispy for optimal texture and flavor.